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About us

The Oxford Parkinson's Disease Centre (OPDC) is a unique multidisciplinary research centre at the University of Oxford supported by Parkinson’s UK with funds from The Monument Trust, one of the Sainsbury Family Charitable Trusts.

Established in February 2010, the Oxford Parkinson’s Disease Centre (OPDC) brings together internationally-renowned scientists who work on the genetics of Parkinson’s, the generation of cell and animal models, and the wiring of brain circuits which control movement, with clinical experts in the diagnosis and treatment of Parkinson’s.

Our world-class research centre was formed to understand the earliest events in the development of Parkinson’s and create animal models with greater relevance to the disease, ultimately with a view to identifying the changes which occur before the symptoms become apparent.

Our programme targets the molecular pathways to Parkinson’s in order to:

  1. Understand the progression of Parkinson’s
  2. Predict the onset of Parkinson’s
  3. Identify potential drug targets for Parkinson’s
  4. Develop new treatments that will prevent the development of Parkinson’s in at-risk individuals.
  • Watch the video below to learn more about OPDC's research

 

Selected Publications

News

Researchers develop a stem cell-based model of mitochondrial disease

Researchers develop a stem cell-based model of mitochondrial disease

Posted 09/04/2018

Mitochondria are the energy-producing factories inside cells. Sometimes genetic mutations can cause these factories to go wrong, leading to a number of neurological diseases. The same genetic mutation affecting mitochondrial function can result in a specific deficit such as loss of vision or a more complicated disorder such as Parkinson’s-like disease.  It is not yet known why the same mutation can have such varying effects. One gene that ...


Brain Awareness Week 2018

Brain Awareness Week 2018

Posted 23/03/2018

March 12-16th 2018 marked Brain Awareness Week with neuroscientists meeting the public to talk about research. OPDC's Imaging lead Professor Clare Mackay and Masud Husain, Professor of Neurology and Cognitive Neuroscience, spoke at a talk open to all about "New developments in Parkinson’s and Alzheimer’s research". In this accessible and informative public talk they explored the latest research into the debilitating neurodegenerative ...


Running for research

Running for research

Posted 19/02/2018

Huge congratulations are in order for DPhil Student Rebecca Wallings, who completed the Dorney Lake Winter Half-Marathon this weekend, in order to raise money for Parkinson’s UK. Becky is a researcher in Richard Wade-Martin’s lab where she is trying to understand what role LRRK2 plays in Parkinson's. Becky had signed up to the Windsor Half-Marathon, but the event was cancelled due to the snow. Becky finished the race in an impressive 2hrs 9 ...

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Seminars/Events

Vladyslav Vyazovskiy 16 May 2018

Vladyslav Vyazovskiy 16 May 2018

Posted 21/03/2018

Associate Professor of Neuroscience Sleep, brain and behaviour laboratory In the last decades a vast empirical and theoretical knowledge about sleep mechanisms has been accumulated. Surprisingly, the function of sleep still remains elusive. Moreover, in place of the long-standing question “why do we sleep?” now comes a more fundamental one: “what is sleep?” Among the key features of sleep are: a) the occurrence of slow waves in NREM sleep ...

Hélène Plun-Favreau - 13 June 2018

Hélène Plun-Favreau - 13 June 2018

Posted 21/03/2018

Mitophagy modulation as a potential therapeutic target for neurodegenerative diseases UCL Institute of Neurology In recent years, it has become clear that even in clinically distinct neurodegenerative conditions, there are common underlying themes in how the neurons become sick and die. One such theme is a breakdown in the maintenance of mitochondria, which plays a central role in Parkinson’s disease and in other neurodegenerative ...

 
Med Sci
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