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About us

The Oxford Parkinson's Disease Centre (OPDC) is a unique multidisciplinary research centre at the University of Oxford supported by Parkinson’s UK with funds from The Monument Trust, one of the Sainsbury Family Charitable Trusts.

Established in February 2010, the Oxford Parkinson’s Disease Centre (OPDC) brings together internationally-renowned scientists who work on the genetics of Parkinson’s, the generation of cell and animal models, and the wiring of brain circuits which control movement, with clinical experts in the diagnosis and treatment of Parkinson’s.

Our world-class research centre was formed to understand the earliest events in the development of Parkinson’s and create animal models with greater relevance to the disease, ultimately with a view to identifying the changes which occur before the symptoms become apparent.

Our programme targets the molecular pathways to Parkinson’s in order to:

  1. Understand the progression of Parkinson’s
  2. Predict the onset of Parkinson’s
  3. Identify potential drug targets for Parkinson’s
  4. Develop new treatments that will prevent the development of Parkinson’s in at-risk individuals.
Watch the video below to see OPDC's Michele Hu talk about our research at Parkinson's UK's Bespoke Treatment Lectures at the Royal Institution.



OPDC scientists map the origins and activities of nerve cells important for movement

OPDC scientists map the origins and activities of nerve cells important for movement

Posted 27/04/2015

New Publication from Paul Dodson et al., in the journal Neuron. Nerve cells in a brain region called the external globus pallidus (GPe) are essential for proper movement. To fully understand the movement difficulties of people with Parkinson’s disease, it is important to define the code of electrical impulses used by GPe cells in the healthy brain. In this new paper, OPDC scientists have discovered that the electrical activities of two types ...

OPDC develop new method to look for Parkinson's Biomarkers

OPDC develop new method to look for Parkinson's Biomarkers

Posted 20/03/2015

The OPDC aims to understand the earliest events that lead to Parkinson’s.  Recently we have made exciting discoveries about the role of alpha-synuclein oligomers in Parkinson’s in a study of post-mortem brain tissue from people with Parkinson’s and healthy controls.    During the development of Parkinson’s the protein alpha-synuclein begins to function abnormally and clumps together to form small clusters, known as oligomers.  Alpha-synuclein ...


Seminar 16 April 2015: Philipp Khael

Posted 07/04/2015

Age-related neurodegenerative diseases are a severe and increasingly worrisome burden for our aging population. Most of the chronic neurodegenerative diseases (Parkinson’s disease [PD], Lewy body dementia [LBD], Alzheimer’s disease, frontotemporal dementia [FTD], amyotrophic lateral sclerosis [ALS], etc.) are characterized by intracellular protein inclusions that are specific for each of these diseases. Professor Khael's group investigate the ...

OPDC Research Day - April 20 2015

OPDC Research Day - April 20 2015

Posted 13/02/2015

The 2015 OPDC Research Day will be held in the Mathematical Institute, Oxford. The day will start at 9am with a day of talks and  poster sessions on Parkinson's research. This will be followed by a drinks reception from 5-7pm. Keynote speakers Professor Donald Grosset, Dr Alex Whitworth and Professor Jochen Roeper. Attendance is free, but registration is required by 10th April 2015 via our research day website. Abstract Submission Deadline ...