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About us

The Oxford Parkinson's Disease Centre (OPDC) is a unique multidisciplinary research centre at the University of Oxford supported by Parkinson’s UK with funds from The Monument Trust, one of the Sainsbury Family Charitable Trusts.

Established in February 2010, the Oxford Parkinson’s Disease Centre (OPDC) brings together internationally-renowned scientists who work on the genetics of Parkinson’s, the generation of cell and animal models, and the wiring of brain circuits which control movement, with clinical experts in the diagnosis and treatment of Parkinson’s.

Our world-class research centre was formed to understand the earliest events in the development of Parkinson’s and create animal models with greater relevance to the disease, ultimately with a view to identifying the changes which occur before the symptoms become apparent.

Our programme targets the molecular pathways to Parkinson’s in order to:

  1. Understand the progression of Parkinson’s
  2. Predict the onset of Parkinson’s
  3. Identify potential drug targets for Parkinson’s
  4. Develop new treatments that will prevent the development of Parkinson’s in at-risk individuals.
Watch the video below to see OPDC's Michele Hu talk about our research at Parkinson's UK's Bespoke Treatment Lectures at the Royal Institution.

 

Selected Publications

News

OPDC research finds people with sleep disorders and Parkinson's have differences in fMRI scans

OPDC research finds people with sleep disorders and Parkinson's have differences in fMRI scans

Posted 22/06/2016

OPDC Clinical Research Fellow Dr Michal Rolinski and other OPDC investigators have recently published their new results in the journal "Brain". Dr Rolinski's research focused on people with REM sleep behaviour disorder (RBD) and Parkinson's using resting-state fMRI.  These brain scans could find differences in cases of RBD and Parkinson's from controls with high sensitivity (96%) and specificity (74-78%). These scans suggest the network connectiv ...

Michele Hu: International Clinical Trials Day Podcast

Michele Hu: International Clinical Trials Day Podcast

Posted 08/06/2016

As part of International Clinical Trials Day on May 20th, OPDC's Michele Hu spoke with Parkinson's UK about why it's important for professionals to support their patients to participate in research, and gives advice about how those interested in research can get started.

'Parkinson's: The Funny Side' on BBC One

'Parkinson's: The Funny Side' on BBC One

Posted 25/04/2016

  The Inside Out special, 'Parkinson's: The Funny Side', which was shown on BBC One on Monday 7th March and Wednesday 20th April is now available to view on iPlayer until 20th May 2016. Paul Mayhew-Archer, one of the writers of Mrs Brown's Boys and The Vicar of Dibley, who was diagnosed with Parkinson's disease five years ago, decided to find out what was being done to develop treatments. In the last few months, Paul has visited the OPDC to ...

Dopamine nerve cells pause to signal movement

Dopamine nerve cells pause to signal movement

Posted 31/03/2016

Movement problems in Parkinson’s disease arise when brain nerve cells releasing the signaling chemical dopamine stop working properly and die. Exactly how dopamine-releasing nerve cells control movement, and how their activity might be disturbed well before their death in disease, are unknown. To address these key issues, Paul Dodson and colleagues at the MRC Brain Network Dynamics Unit and Oxford Parkinson’s Disease Centre recorded the electrica ...

Seminars/Events

Mark Cooper Seminar - 12th July

Mark Cooper Seminar - 12th July

Posted 20/04/2016

Seminar Title: 'Cellular processing of Alpha-synuclein : implications for Parkinson’s Disease' Dr Mark Cooper trained in the field of mitochondrial biochemistry in disease under the supervision of Dr John Morgan-Hughes and Professor John Clark (PhD 1987) at the Institute of Neurology, London. Dr Cooper was appointed as Lecturer in the Department of Protein and Molecular Biology at the Royal Free Hospital Medical School, and subsequently in 1 ...

John Reynolds Seminar - 27 Sept 2016

John Reynolds Seminar - 27 Sept 2016

Posted 28/06/2016

Seminar Title: 'TBC' His research team studies the application of neuroplasticity approaches to Parkinson’s disease and stroke. His interest is in applying the principles of neuromodulation to modify synaptic plasticity and recover function in affected brain areas.  The primary focus of his research is on learning and movement generation processes in the basal ganglia and cerebral cortex. In the basal ganglia the emphasis is on unraveling t ...

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