Brent Ryan

Brent Ryan

Career Development Fellow

Brent’s research focusses on identifying biochemical phenotypes in dopaminergic neurons, reprogrammed from Parkinson’s patients, and using these phenotypes to screen for novel drugs to treat Parkinson’s. This process involves differentiating patient-derived iPSCs, reprogrammed in the laboratory of OPDC member Sally Cowley, into dopaminergic neuronal cultures. In collaboration with a number of other members of Richard Wade-Martins’ lab, Brent uses proteomics and a range of reporter assays to identify phenotypes in cultures taken from PD patients, such as perturbed autophagy or mitochondrial dysfunction. Brent then develops assays for these phenotypes which can be used as the basis for high-throughput screens to identify compounds which may eventually be used to treat Parkinson’s.

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